TIAM1 exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-3928642
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TIAM1 exchanges GTP for GDP on RAC1, activating it
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activation of EPH receptors triggers the local activation of T-lymphoma invasion and metastasis-inducing protein 1 (TIAM1) and this in turn activates RAC1 (Yoo et al. 2010). RAC1 signaling is positively linked to EPH:ephrin (EFN) internalization but the exact link to clathrin endocytosis machinery remains unclear. TIAM1 co-localizes with the ARP2/3 complex at sites of actin polymerization. RAC1 activated by TIAM1 then subsequently activates the ARP2/3 complex proteins leading to actin polymerization (Ten Klooster et al. 2006).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane]

Physical Entity
EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
TIAM1 exchanges GTP for GDP on RAC1, activating it (Caenorhabditis elegans)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Danio rerio)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Drosophila melanogaster)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Gallus gallus)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Mus musculus)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Sus scrofa)
TIAM1 exchanges GTP for GDP on RAC1, activating it (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
Cite Us!