Reactome | PAKs autophosphorylate

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PAKs autophosphorylate Show undefined attributes

authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity	[CatalystActivity:3928575] protein serine/threonine kinase activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
dbId	3928625
displayName	PAKs autophosphorylate
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
entityOnOtherCell	[DefinedSet:R-HSA-3928335] EPHBs [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-3928664] Ephrin signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-3928640] PAKs phosphorylate MLC - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-3928537] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3928202] A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC [LiteratureReference:4640885] Biology of the p21-activated kinases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PAKs autophosphorylate
orthologousEvent	[Reaction:R-CEL-3928625] PAKs autophosphorylate - Caenorhabditis elegans [Reaction:R-DME-3928625] PAKs autophosphorylate - Drosophila melanogaster [Reaction:R-GGA-3928625] PAKs autophosphorylate - Gallus gallus [Reaction:R-XTR-3928625] PAKs autophosphorylate - Xenopus tropicalis [Reaction:R-DRE-3928625] PAKs autophosphorylate - Danio rerio [Reaction:R-SSC-3928625] PAKs autophosphorylate - Sus scrofa [Reaction:R-BTA-3928625] PAKs autophosphorylate - Bos taurus [Reaction:R-CFA-3928625] PAKs autophosphorylate - Canis familiaris [Reaction:R-RNO-3928625] PAKs autophosphorylate - Rattus norvegicus [Reaction:R-MMU-3928625] PAKs autophosphorylate - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-3928534] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3928641] PAK binds RAC and bPIX - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3928625
summation	[Summation:3928276] PAK is also locally activated in the synapse. PAK1 needs aut...

Referrals

(precedingEvent)	[Reaction:R-HSA-3928640] PAKs phosphorylate MLC
(hasEvent)	[Pathway:R-HSA-3928664] Ephrin signaling