Reactome | PAKs autophosphorylate

PAKs autophosphorylate

Stable Identifier

R-HSA-3928625

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PAK is also locally activated in the synapse. PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the two conserved sites that regulate the catalytic activity (Bokoch 2003).

Literature References

PubMed ID	Title	Journal	Year
12676796	Biology of the p21-activated kinases Bokoch, GM	Annu. Rev. Biochem.	2003
15800193	A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H, Niu, S	J. Neurosci.	2005