PAKs autophosphorylate

Stable Identifier
R-HSA-3928625
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PAK is also locally activated in the synapse. PAK1 needs autophosphorylation for complete activation. PAK1 is autophosphorylated at several sites, but serine 144 (S144) in the GTPase-binding domain and threonine 423 (T423) in the activation loop are the two conserved sites that regulate the catalytic activity (Bokoch 2003).

Literature References
PubMed ID Title Journal Year
15800193 A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

Zhang, H, Webb, DJ, Asmussen, H, Niu, S, Horwitz, AF

J. Neurosci. 2005
12676796 Biology of the p21-activated kinases

Bokoch, GM

Annu. Rev. Biochem. 2003
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created