Reactome | Ephrin signaling

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Ephrin signaling Show undefined attributes

authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3928666] Garapati, P V, 2013-07-22
dbId	3928664
displayName	Ephrin signaling
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
eventOf	[Pathway:R-HSA-2682334] EPH-Ephrin signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3928615] EFNBs bind SFKs - Homo sapiens [Reaction:R-HSA-3928580] SFKs phosphorylate EFNBs - Homo sapiens [Reaction:R-HSA-3928639] p-EFNB binds GRB4 - Homo sapiens [Reaction:R-HSA-3928594] SFKs phosphorylate GIT1 - Homo sapiens [Reaction:R-HSA-3928614] EFNB:GRB4 binds GIT1 - Homo sapiens [Reaction:R-HSA-3928631] GIT1 binds bPIX - Homo sapiens [Reaction:R-HSA-3928633] bPIX exchanges GTP for GDP on RAC, activating it - Homo sapiens [Reaction:R-HSA-3928641] PAK binds RAC and bPIX - Homo sapiens [Reaction:R-HSA-3928625] PAKs autophosphorylate - Homo sapiens [Reaction:R-HSA-3928640] PAKs phosphorylate MLC - Homo sapiens [Reaction:R-HSA-4093329] EFNBs bind SDCBP - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:4640884] Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Ephrin signaling
orthologousEvent	[Pathway:R-CEL-3928664] Ephrin signaling - Caenorhabditis elegans [Pathway:R-DME-3928664] Ephrin signaling - Drosophila melanogaster [Pathway:R-GGA-3928664] Ephrin signaling - Gallus gallus [Pathway:R-XTR-3928664] Ephrin signaling - Xenopus tropicalis [Pathway:R-DRE-3928664] Ephrin signaling - Danio rerio [Pathway:R-SSC-3928664] Ephrin signaling - Sus scrofa [Pathway:R-BTA-3928664] Ephrin signaling - Bos taurus [Pathway:R-CFA-3928664] Ephrin signaling - Canis familiaris [Pathway:R-RNO-3928664] Ephrin signaling - Rattus norvegicus [Pathway:R-MMU-3928664] Ephrin signaling - Mus musculus
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3928664
summation	[Summation:3928277] The interaction between ephrin (EFN) ligands and EPH recepto...
updateTrackers	[UpdateTracker:9781733] Update Tracker - [Pathway:3928664] Ephrin signaling - v60:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9781733] Update Tracker - [Pathway:3928664] Ephrin signaling - v60:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-2682334] EPH-Ephrin signaling