Reactome | L1 binds to AP-2 Clathrin complex

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L1 binds to AP-2 Clathrin complex Show undefined attributes

authored	[InstanceEdit:374671] Garapati, P V, 2008-07-30 10:22:58
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:392750] Garapati, P V, 2009-03-07 11:31:09
dbId	392748
displayName	L1 binds to AP-2 Clathrin complex
edited	[InstanceEdit:374671] Garapati, P V, 2008-07-30 10:22:58
eventOf	[Pathway:R-HSA-437239] Recycling pathway of L1 - Homo sapiens
followingEvent	[Reaction:R-HSA-555065] Formation of clathrin coated vesicle - Homo sapiens [Reaction:R-HSA-392749] Transport of L1 into endosomes - Homo sapiens
input	[Complex:R-HSA-177505] Clathrin:AP-2 complex [plasma membrane] [EntityWithAccessionedSequence:R-HSA-191465] L1CAM [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:392731] The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	L1 binds to AP-2 Clathrin complex
orthologousEvent	[Reaction:R-CEL-392748] L1 binds to AP-2 Clathrin complex - Caenorhabditis elegans [Reaction:R-DME-392748] L1 binds to AP-2 Clathrin complex - Drosophila melanogaster [Reaction:R-GGA-392748] L1 binds to AP-2 Clathrin complex - Gallus gallus [Reaction:R-RNO-392748] L1 binds to AP-2 Clathrin complex - Rattus norvegicus [Reaction:R-MMU-392748] L1 binds to AP-2 Clathrin complex - Mus musculus
output	[Complex:R-HSA-555064] L1:clathrin-coated vesicle [plasma membrane]
precedingEvent	[Reaction:R-HSA-445089] Dephosphorylation of pL1 (Y1176) - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513001] Maness, PF, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392748
summation	[Summation:392732] L1 in the C-domain membrane is internalized via clathrin med...

Referrals

(precedingEvent)	[Reaction:R-HSA-555065] Formation of clathrin coated vesicle [Reaction:R-HSA-392749] Transport of L1 into endosomes
(hasEvent)	[Pathway:R-HSA-437239] Recycling pathway of L1

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