L1 in the C-domain membrane is internalized via clathrin med...

created [InstanceEdit:392729] Garapati, P V, 2009-03-07 11:16:53
dbId 392732
displayName L1 in the C-domain membrane is internalized via clathrin med...
literatureReference
modified [InstanceEdit:447049] Garapati, P V, 2009-11-19
schemaClass Summation
text L1 in the C-domain membrane is internalized via clathrin mediated endocytosis. The assembly of clathrin coats at the plasma membrane depends on the adaptor complex AP-2 which is composed of two large chains (alpha and beta1 or beta2 adaptin), one medium (mu2) chain, and one small chain (sigma2). When dephosphorylated, the sorting signal/endocytic motif YRSLE sequence enables L1 to directly bind the mu2 subunit of AP-2, and concentrates L1 molecules in clathrin coated areas of the plasma membrane.
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