Reactome | L1 binds to AP-2 Clathrin complex

L1 binds to AP-2 Clathrin complex

Stable Identifier

R-HSA-392748

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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L1 in the C-domain membrane is internalized via clathrin mediated endocytosis. The assembly of clathrin coats at the plasma membrane depends on the adaptor complex AP-2 which is composed of two large chains (alpha and beta1 or beta2 adaptin), one medium (mu2) chain, and one small chain (sigma2). When dephosphorylated, the sorting signal/endocytic motif YRSLE sequence enables L1 to directly bind the mu2 subunit of AP-2, and concentrates L1 molecules in clathrin coated areas of the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
9651214	The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway Kamiguchi, H, Long, KE, Pendergast, M, Schaefer, AW, Rapoport, I, Kirchhausen, T, Lemmon, V	J Neurosci	1998