G-proteins in the Gi class inhibit adenylate cyclase activit...

created [InstanceEdit:400697] Jupe, S, 2009-03-24 17:56:07
dbId 400698
displayName G-proteins in the Gi class inhibit adenylate cyclase activit...
literatureReference
modified [InstanceEdit:449169] Jupe, S, 2009-11-30
schemaClass Summation
text G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.
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