G alpha (z) inhibits adenylate cyclase

Stable Identifier
R-HSA-392064
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.

Literature References
PubMed ID Title Journal Year
7595566 Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins

Chan, JS, Chiu, TT, Wong, YH

J Neurochem 1995
1347957 Gz-mediated hormonal inhibition of cyclic AMP accumulation

Wong, YH, Conklin, BR, Bourne, HR

Science 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created