G alpha (z) inhibits adenylate cyclase

Stable Identifier
R-HSA-392064
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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G alpha (z) inhibits adenylate cyclase
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G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.
Literature References
PubMed ID Title Journal Year
1347957 Gz-mediated hormonal inhibition of cyclic AMP accumulation

Conklin, BR, Wong, YH, Bourne, HR

Science 1992
7595566 Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins

Chiu, TT, Chan, JS, Wong, YH

J Neurochem 1995
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Orthologous Events
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G alpha (z) inhibits adenylate cyclase (Xenopus tropicalis)
Authored
Jupe, S  (2009-02-26)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-02-26)
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