Reactome | HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA

Schema > Reaction > Entries

HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA Show undefined attributes

authored	[InstanceEdit:398115] D'Eustachio, P, 2009-03-16 18:50:14
catalystActivity	[CatalystActivity:193365] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of HSD17B4 dimer [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:390243] D'Eustachio, P, 2009-01-23 17:38:45
crossReference	[DatabaseIdentifier:12667578] RHEA:78637 [DatabaseIdentifier:9914146] RHEA:78637
dbId	390251
displayName	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA
edited	[InstanceEdit:398202] D'Eustachio, P, 2009-03-18 13:33:40
eventOf	[Pathway:R-HSA-390247] Beta-oxidation of very long chain fatty acids - Homo sapiens
followingEvent	[Reaction:R-HSA-390250] 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA - Homo sapiens [Reaction:R-HSA-9856871] MDH1 reduces OA - Homo sapiens
input	[SimpleEntity:R-ALL-390248] 3-hydroxyhexacosanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-192307] NAD+ [peroxisomal matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:389997] Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis [LiteratureReference:192311] Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase [LiteratureReference:389983] Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA 3R)-hydroxyhexacosanoyl-CoA + NAD(+) => 3-oxohexacosanoyl-CoA + H(+) + NADH 3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+ (HSD17B4)
orthologousEvent	[Reaction:R-RNO-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Rattus norvegicus [Reaction:R-DDI-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Dictyostelium discoideum [Reaction:R-CEL-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Caenorhabditis elegans [Reaction:R-DME-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Drosophila melanogaster [Reaction:R-GGA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Gallus gallus [Reaction:R-BTA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Bos taurus [Reaction:R-CFA-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Canis familiaris [Reaction:R-MMU-390251] HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-390241] 3-ketohexacosanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-192305] NADH [peroxisomal matrix]
precedingEvent	[Reaction:R-HSA-390252] HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA - Homo sapiens [Reaction:R-HSA-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:392190] Jassal, Bijay, 2009-02-27
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-390251
summation	[Summation:390259] Peroxisomal HSD17B4 dimer catalyzes the reaction of 3-hydrox...

Referrals

(precedingEvent)	[Reaction:R-HSA-390250] 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA [Reaction:R-HSA-9856871] MDH1 reduces OA
(hasEvent)	[Pathway:R-HSA-390247] Beta-oxidation of very long chain fatty acids

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