Peroxisomal HSD17B4 dimer catalyzes the reaction of 3-hydrox...

created [InstanceEdit:390243] D'Eustachio, P, 2009-01-23 17:38:45
dbId 390259
displayName Peroxisomal HSD17B4 dimer catalyzes the reaction of 3-hydrox...
schemaClass Summation
text Peroxisomal HSD17B4 dimer catalyzes the reaction of 3-hydroxyhexacosanoyl-CoA and NAD+ to form 3-ketohexacosanoyl-CoA and NADH + H+. The enzyme is bifunctional - an aminoterminal domain catalyzes the dehydrogenation of a variety of 3-hydroxyacyl-CoA's, the reaction annotated here, and a carboxyterminal domain catalyzes the hydration of a variety of trans-2,3-dehydroacyl-CoA's (Jiang et al. 1996, 1997). Defects in the enzyme are associated with a severe disorder of peroxisomal fatty acid metabolism in humans (Ferdinandusse et al. 2006).
Cite Us!