AKT interacts and phosphorylates Cot

Stable Identifier
R-HSA-389756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cot/Tpl 2 is a serine/threonine kinase of the mitogen activated protein kinase kinase kinase (MAP3K) family. Cot is observed as one of the downstream effectors of Akt. Based on in-vitro kinase assays and following overexpression in cell lines its been showed that AKT can phosphorylate Cot under non-physiological conditions. Akt and Cot physically interact through the amino terminus of Cot, and this interaction results in the phosphorylation of Cot on serine 400. Cot was shown to activate the IkB kinase (IKK) complex, possibly acting through NF kB inducing kinase (NIK).

Literature References
PubMed ID Title Journal Year
12138205 Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

Kane, LP, Mollenauer, MN, Xu, Z, Turck, CW, Weiss, A

Mol Cell Biol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created