Reactome | DVL is recruited to the receptor

DVL is recruited to the receptor

Stable Identifier

R-HSA-3858482

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The DEP domain of dishevelled proteins (DVL) is required both for planar cell polarization (PCP) signaling and for membrane localization upon WNT activation (Boutros et al, 1998; Axelrod et al, 2001; Rothbacher et al, 2000, Wong et al, 2000; Park et al, 2005; Witzel et al, 2006). Although DVL interacts with FZD through its PDZ domain, disruption of this binding interface does not interfere with non-canonical signaling (Wong et al, 2003). Membrane recruitment of DVL and establishment of PCP may also rely on other interacting partners (Lee et al, 2007; Li et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
17130287	Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane Heisenberg, CP, Tada, M, Carreira-Barbosa, F, Witzel, S, Zimyanin, V	J. Cell Biol.	2006
15936275	Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos Sato, A, Gray, RS, Habas, R, Wallingford, JB, Park, TJ	Curr. Biol.	2005
11101902	Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway Wong, HC, Liu, B, Nguyen, JT, Li, L, Srinivas, S, Zheng, J, Mao, J, Zhang, W, Wu, D	Nat. Struct. Biol.	2000
12015986	Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling Axelrod, JD, Tree, DR, Shulman, JM, Gubb, D, Scott, MP, Rousset, R	Cell	2002
10698942	Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis Laurent, MN, Rothbächer, U, Klein, PS, Deardorff, MA, Cho, KW, Fraser, SE	EMBO J.	2000
23821037	Gpr125 modulates Dishevelled distribution and planar cell polarity signaling Li, X, Ni, M, Roszko, I, Marlow, FL, Hamm, HE, Solnica-Krezel, L, Sepich, DS	Development	2013
9674432	Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling Boutros, M, Mlodzik, M, Paricio, N, Strutt, DI	Cell	1998
9716412	Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways Axelrod, JD, Shulman, JM, Miller, JR, Perrimon, N, Moon, RT	Genes Dev	1998
17627283	XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway Kinoshita, N, Natsume, T, Iioka, H, Ohashi, M, Iemura, S, Lee, RH	EMBO J.	2007
11358862	Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling Axelrod, JD	Genes Dev.	2001
14636582	Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled Shi, DL, Zheng, J, Wu, D, Shao, Y, Wong, HC, Lee, HJ, Bourdelas, A, Mlodzik, M, Krauss, A	Mol Cell	2003