Reactome | HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1

Schema > Reaction > Entries

HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 Show undefined attributes

catalystActivity	[CatalystActivity:10957509] serine-type endopeptidase activity of Collagen type VII NC2 proteinases [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10961415
displayName	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
eventOf	[Pathway:R-CEL-1474228] Degradation of the extracellular matrix - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 - Homo sapiens
input	[DefinedSet:R-CEL-1011570-4] Homologues of HSPG2(22-4391) [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1
output	[DefinedSet:R-CEL-3827968-4] Homologues of HSPG2(22-4196) [extracellular region] [DefinedSet:R-CEL-3827980-4] Homologues of HSPG2(4197-4391) [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-3814820
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-1474228] Degradation of the extracellular matrix
(inferredTo)	[Reaction:R-HSA-3814820] HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1

Cite Us!