Reactome | Thrombin proteolyzes IGF:IGFBP3:ALS

Schema > Reaction > Entries

Thrombin proteolyzes IGF:IGFBP3:ALS Show undefined attributes

catalystActivity	[CatalystActivity:10113243] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10133903
displayName	Thrombin proteolyzes IGF:IGFBP3:ALS
eventOf	[Pathway:R-RNO-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-381446] Thrombin proteolyzes IGF:IGFBP3:ALS - Homo sapiens
input	[Complex:R-RNO-381536] IGF:IGFBP3:ALS [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Thrombin proteolyzes IGF:IGFBP3:ALS
output	[DefinedSet:R-RNO-381451] IGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-RNO-381498] Igfals [extracellular region] [EntityWithAccessionedSequence:R-RNO-381547] Igfbp3 [extracellular region] [EntityWithAccessionedSequence:R-RNO-381465] Igfbp3 [extracellular region] [EntityWithAccessionedSequence:R-RNO-381546] Igfbp3 [extracellular region]
precedingEvent	[Reaction:R-RNO-381496] Formation of the IGF:IGFBP3:ALS complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-381446
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
(inferredTo)	[Reaction:R-HSA-381446] Thrombin proteolyzes IGF:IGFBP3:ALS