Reactome | p-S724-IRE1 dimer [endoplasmic reticulum membrane]

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p-S724-IRE1 dimer [endoplasmic reticulum membrane] Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane
componentOf	[Complex:R-HSA-381078] p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP - Homo sapiens
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	381154
displayName	p-S724-IRE1 dimer [endoplasmic reticulum membrane]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-381029] p-S724-ERN1 [endoplasmic reticulum membrane]
inDisease	false
inferredTo	[Complex:R-MMU-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Mus musculus [Complex:R-RNO-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Rattus norvegicus [Complex:R-CFA-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Canis familiaris [Complex:R-BTA-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Bos taurus [Complex:R-XTR-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Xenopus tropicalis [Complex:R-GGA-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Gallus gallus [Complex:R-DME-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Drosophila melanogaster [Complex:R-CEL-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Caenorhabditis elegans [Complex:R-DDI-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Dictyostelium discoideum [Complex:R-SPO-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Schizosaccharomyces pombe [Complex:R-SCE-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - Saccharomyces cerevisiae
literatureReference	[LiteratureReference:535482] A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells [LiteratureReference:535571] The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response [LiteratureReference:535483] The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
maxDepth	2
modified	[InstanceEdit:5261522] May, B, 2014-02-07
name	p-S724-IRE1 dimer
producedByEvent	[Reaction:R-HSA-381091] IRE1 dimer autophosphorylates - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-381154
summation	[Summation:381196] After juxtaposition of the luminal N-termini of IRE1 to form...
updateTrackers	[UpdateTracker:9869437] Update Tracker - [Complex:381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - v33:[add_removeLiteratureReference] [UpdateTracker:9888989] Update Tracker - [Complex:381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - v48:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9869437] Update Tracker - [Complex:381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - v33:[add_removeLiteratureReference] [UpdateTracker:9888989] Update Tracker - [Complex:381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane] - v48:[modifyName]
(output)	[Reaction:R-HSA-381091] IRE1 dimer autophosphorylates
(input)	[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP
(hasComponent)	[Complex:R-HSA-381078] p-S724-IRE1 dimer:ADP [endoplasmic reticulum membrane]

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