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Entries
IRE1 dimer autophosphorylates
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authored
[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
catalystActivity
[CatalystActivity:381048] protein serine/threonine kinase activity of IRE1 dimer [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId
381091
displayName
IRE1 dimer autophosphorylates
edited
[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf
[Pathway:R-HSA-381070] IRE1alpha activates chaperones - Homo sapiens
figure
[Figure:381187] /figures/UPR-IRE1dimerization.jpg
followingEvent
[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-381200] IRE1 dimer [endoplasmic reticulum membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:535482] A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
[LiteratureReference:535571] The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
[LiteratureReference:535483] The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
IRE1 dimer autophosphorylates
orthologousEvent
[Reaction:R-SCE-381091] IRE1 dimer autophosphorylates - Saccharomyces cerevisiae
[Reaction:R-SPO-381091] IRE1 dimer autophosphorylates - Schizosaccharomyces pombe
[Reaction:R-DDI-381091] IRE1 dimer autophosphorylates - Dictyostelium discoideum
[Reaction:R-CEL-381091] IRE1 dimer autophosphorylates - Caenorhabditis elegans
[Reaction:R-DME-381091] IRE1 dimer autophosphorylates - Drosophila melanogaster
[Reaction:R-GGA-381091] IRE1 dimer autophosphorylates - Gallus gallus
[Reaction:R-XTR-381091] IRE1 dimer autophosphorylates - Xenopus tropicalis
[Reaction:R-BTA-381091] IRE1 dimer autophosphorylates - Bos taurus
[Reaction:R-CFA-381091] IRE1 dimer autophosphorylates - Canis familiaris
[Reaction:R-RNO-381091] IRE1 dimer autophosphorylates - Rattus norvegicus
[Reaction:R-MMU-381091] IRE1 dimer autophosphorylates - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-381109] IRE1 binds IRE1 forming dimer - Homo sapiens
releaseDate
2009-06-24
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
[InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-381091
summation
[Summation:381011] Dimerization of the N-terminal luminal regions of IRE1-alpha...
Referrals
(hasEvent)
[Pathway:R-HSA-381070] IRE1alpha activates chaperones
(precedingEvent)
[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP
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