Reactome | IRE1 dimer autophosphorylates

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IRE1 dimer autophosphorylates Show undefined attributes

authored	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
catalystActivity	[CatalystActivity:381048] protein serine/threonine kinase activity of IRE1 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	381091
displayName	IRE1 dimer autophosphorylates
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf	[Pathway:R-HSA-381070] IRE1alpha activates chaperones - Homo sapiens
figure	[Figure:381187] /figures/UPR-IRE1dimerization.jpg
followingEvent	[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-381200] IRE1 dimer [endoplasmic reticulum membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:535482] A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells [LiteratureReference:535571] The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response [LiteratureReference:535483] The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	IRE1 dimer autophosphorylates
orthologousEvent	[Reaction:R-SCE-381091] IRE1 dimer autophosphorylates - Saccharomyces cerevisiae [Reaction:R-SPO-381091] IRE1 dimer autophosphorylates - Schizosaccharomyces pombe [Reaction:R-DDI-381091] IRE1 dimer autophosphorylates - Dictyostelium discoideum [Reaction:R-CEL-381091] IRE1 dimer autophosphorylates - Caenorhabditis elegans [Reaction:R-DME-381091] IRE1 dimer autophosphorylates - Drosophila melanogaster [Reaction:R-GGA-381091] IRE1 dimer autophosphorylates - Gallus gallus [Reaction:R-XTR-381091] IRE1 dimer autophosphorylates - Xenopus tropicalis [Reaction:R-BTA-381091] IRE1 dimer autophosphorylates - Bos taurus [Reaction:R-CFA-381091] IRE1 dimer autophosphorylates - Canis familiaris [Reaction:R-RNO-381091] IRE1 dimer autophosphorylates - Rattus norvegicus [Reaction:R-MMU-381091] IRE1 dimer autophosphorylates - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-381109] IRE1 binds IRE1 forming dimer - Homo sapiens
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-381091
summation	[Summation:381011] Dimerization of the N-terminal luminal regions of IRE1-alpha...
updateTrackers	[UpdateTracker:9790425] Update Tracker - [Reaction:381091] IRE1 dimer autophosphorylates - v33:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9790425] Update Tracker - [Reaction:381091] IRE1 dimer autophosphorylates - v33:[add_removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-381070] IRE1alpha activates chaperones
(precedingEvent)	[Reaction:R-HSA-381116] Phosphorylated IRE1 dimer binds ADP

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