Reactome | IRE1 dimer autophosphorylates

Schema > Reaction > Entries

IRE1 dimer autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10012115] protein serine/threonine kinase activity of IRE1 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10012117
displayName	IRE1 dimer autophosphorylates
eventOf	[Pathway:R-MMU-381070] IRE1alpha activates chaperones - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-381091] IRE1 dimer autophosphorylates - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-381200] IRE1 dimer [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IRE1 dimer autophosphorylates
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-381154] p-S724-IRE1 dimer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-MMU-381109] IRE1 binds IRE1 forming dimer - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-381091
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-381070] IRE1alpha activates chaperones
(inferredTo)	[Reaction:R-HSA-381091] IRE1 dimer autophosphorylates

Cite Us!