Reactome | LKB1 forms a trimeric complex with STRAD and MO25

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LKB1 forms a trimeric complex with STRAD and MO25 Show undefined attributes

authored	[InstanceEdit:380973] Katajisto, P, Makela, T, Wu, J, 2008-11-19
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
dbId	380942
displayName	LKB1 forms a trimeric complex with STRAD and MO25
edited	[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
eventOf	[Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Homo sapiens
followingEvent	[Reaction:R-HSA-200421] Activation of cytosolic AMPK by phosphorylation - Homo sapiens
input	[DefinedSet:R-HSA-380975] MO25 [cytosol] [EntityWithAccessionedSequence:R-HSA-380954] STK11 [cytosol] [DefinedSet:R-HSA-380963] STRAD [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380984] Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD [LiteratureReference:380950] MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	LKB1 forms a trimeric complex with STRAD and MO25
orthologousEvent	[Reaction:R-DDI-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Dictyostelium discoideum [Reaction:R-GGA-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Gallus gallus [Reaction:R-SSC-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Sus scrofa [Reaction:R-BTA-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Bos taurus [Reaction:R-CFA-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Canis familiaris [Reaction:R-RNO-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Rattus norvegicus [Reaction:R-MMU-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Mus musculus
output	[Complex:R-HSA-380967] LKB1:STRAD:MO25 [cytosol]
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-380942
summation	[Summation:380981] Upon complex formation with STRAD and MO25, LKB1 (also known...

Referrals

(hasEvent)	[Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK
(precedingEvent)	[Reaction:R-HSA-200421] Activation of cytosolic AMPK by phosphorylation