LKB1 forms a trimeric complex with STRAD and MO25

Stable Identifier
R-HSA-380942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Upon complex formation with STRAD and MO25, LKB1 (also known as serine/threonine kinase 11, STK11) is mostly cytosolic. LKB1 attains 20x activity towards the substrates belonging to the subfamily of AMPK-like kinases (5'AMP-activated protein kinases).

Literature References
PubMed ID Title Journal Year
14517248 MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Boudeau, J, Baas, AF, Deak, M, Morrice, NA, Kieloch, A, Schutkowski, M, Prescott, AR, Clevers, HC, Alessi, DR

EMBO J 2003
12805220 Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

Baas, AF, Boudeau, J, Sapkota, GP, Smit, L, Medema, R, Morrice, NA, Alessi, DR, Clevers, HC

EMBO J 2003
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