Reactome | LKB1 forms a trimeric complex with STRAD and MO25

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LKB1 forms a trimeric complex with STRAD and MO25 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10133759
displayName	LKB1 forms a trimeric complex with STRAD and MO25
eventOf	[Pathway:R-RNO-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-200421] Activation of cytosolic AMPK by phosphorylation - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Homo sapiens
input	[DefinedSet:R-RNO-380975] MO25 [cytosol] [EntityWithAccessionedSequence:R-RNO-380954] STK11 [cytosol] [DefinedSet:R-RNO-380963] STRAD [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LKB1 forms a trimeric complex with STRAD and MO25
output	[Complex:R-RNO-380967] LKB1:STRAD:MO25 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-380942
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-380972] Energy dependent regulation of mTOR by LKB1-AMPK
(precedingEvent)	[Reaction:R-RNO-200421] Activation of cytosolic AMPK by phosphorylation
(inferredTo)	[Reaction:R-HSA-380942] LKB1 forms a trimeric complex with STRAD and MO25

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