Reactome | Phosphorylated AMPK binds AMP

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Phosphorylated AMPK binds AMP Show undefined attributes

authored	[InstanceEdit:380973] Katajisto, P, Makela, T, Wu, J, 2008-11-19
catalystActivity	[CatalystActivity:9917191] AMP binding activity of p-AMPK heterotrimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
dbId	380930
displayName	Phosphorylated AMPK binds AMP
edited	[InstanceEdit:380970] Jassal, B, 2008-11-19 15:14:38
eventOf	[Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Homo sapiens
followingEvent	[Reaction:R-HSA-1592244] AMPK phosphorylates PPARGC1A - Homo sapiens [Reaction:R-HSA-447074] AMPK phosphorylates Raptor in the mTORC1 complex - Homo sapiens [Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 - Homo sapiens [Reaction:R-HSA-5673768] p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex - Homo sapiens [Reaction:R-HSA-200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis - Homo sapiens [Reaction:R-HSA-163691] Phosphorylation of ChREBP at Serine 556 by AMPK - Homo sapiens
input	[SimpleEntity:R-ALL-76577] AMP [cytosol] [Complex:R-HSA-380934] p-AMPK heterotrimer [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:380939] 5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC [LiteratureReference:380958] Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Phosphorylated AMPK binds AMP
orthologousEvent	[Reaction:R-SCE-380930] Phosphorylated AMPK binds AMP - Saccharomyces cerevisiae [Reaction:R-SPO-380930] Phosphorylated AMPK binds AMP - Schizosaccharomyces pombe [Reaction:R-DDI-380930] Phosphorylated AMPK binds AMP - Dictyostelium discoideum [Reaction:R-CEL-380930] Phosphorylated AMPK binds AMP - Caenorhabditis elegans [Reaction:R-DME-380930] Phosphorylated AMPK binds AMP - Drosophila melanogaster [Reaction:R-GGA-380930] Phosphorylated AMPK binds AMP - Gallus gallus [Reaction:R-DRE-380930] Phosphorylated AMPK binds AMP - Danio rerio [Reaction:R-SSC-380930] Phosphorylated AMPK binds AMP - Sus scrofa [Reaction:R-BTA-380930] Phosphorylated AMPK binds AMP - Bos taurus [Reaction:R-CFA-380930] Phosphorylated AMPK binds AMP - Canis familiaris [Reaction:R-RNO-380930] Phosphorylated AMPK binds AMP - Rattus norvegicus [Reaction:R-MMU-380930] Phosphorylated AMPK binds AMP - Mus musculus
output	[Complex:R-HSA-380931] p-AMPK heterotrimer:AMP [cytosol]
precedingEvent	[Reaction:R-HSA-200421] Activation of cytosolic AMPK by phosphorylation - Homo sapiens
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693188] Zwartkruis, Fried J T, 2015-05-14
revised	[InstanceEdit:5687545] Jupe, Steve, 2015-04-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-380930
summation	[Summation:380978] If AMP:ATP ratio rises, AMP (instead of ATP) is bound by the...
updateTrackers	[UpdateTracker:9919464] Update Tracker - [Reaction:380930] Phosphorylated AMPK binds AMP - v90:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9919464] Update Tracker - [Reaction:380930] Phosphorylated AMPK binds AMP - v90:[removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis [Reaction:R-HSA-1592244] AMPK phosphorylates PPARGC1A [Reaction:R-HSA-163691] Phosphorylation of ChREBP at Serine 556 by AMPK [Reaction:R-HSA-447074] AMPK phosphorylates Raptor in the mTORC1 complex [Reaction:R-HSA-380927] p-AMPK phosphorylates TSC1:TSC2 [Reaction:R-HSA-5673768] p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex
(hasEvent)	[Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK

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