Reactome | Phosphorylated AMPK binds AMP

Phosphorylated AMPK binds AMP

Stable Identifier

R-HSA-380930

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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If AMP:ATP ratio rises, AMP (instead of ATP) is bound by the AMPK-gamma subunit, which inhibits the dephosphorylation of the AMPK-alpha subunit resulting in activation of AMPK. It is not clear, as of yet, whether AMP binds to unphosphorylated AMPK.

Literature References

PubMed ID	Title	Journal	Year
8549768	5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC Davies, SP, Hardie, DG, Helps, NR, Cohen, PT	FEBS Lett	1995
16943194	Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase Neumann, D, Tuerk, R, Wallimann, T, Suter, M, Schlattner, U, Riek, U	J Biol Chem	2006