Reactome | Phosphorylated AMPK binds AMP

Phosphorylated AMPK binds AMP

Stable Identifier

R-HSA-380930

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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If AMP:ATP ratio rises, AMP (instead of ATP) is bound by the AMPK-gamma subunit, which inhibits the dephosphorylation of the AMPK-alpha subunit resulting in activation of AMPK. It is not clear, as of yet, whether AMP binds to unphosphorylated AMPK.

Literature References

PubMed ID	Title	Journal	Year
16943194	Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase Suter, M, Riek, U, Tuerk, R, Schlattner, U, Wallimann, T, Neumann, D	J Biol Chem	2006
8549768	5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC Davies, SP, Helps, NR, Cohen, PT, Hardie, DG	FEBS Lett	1995