If AMP:ATP ratio rises, AMP (instead of ATP) is bound by the AMPK-gamma subunit, which inhibits the dephosphorylation of the AMPK-alpha subunit resulting in activation of AMPK. It is not clear, as of yet, whether AMP binds to unphosphorylated AMPK.
Suter, M, Riek, U, Tuerk, R, Schlattner, U, Wallimann, T, Neumann, D
Davies, SP, Helps, NR, Cohen, PT, Hardie, DG
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