Reactome | SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)

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SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) Show undefined attributes

authored	[InstanceEdit:3777111] May, B, 2013-06-26
catalystActivity	[CatalystActivity:3777114] superoxide dismutase activity of SOD1 dimer [mitochondrial intermembrane space]
catalystActivityReference	[CatalystActivityReference:9644004] superoxide dismutase activity of SOD1 dimer [mitochondrial intermembrane space] Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:3777111] May, B, 2013-06-26
crossReference	[DatabaseIdentifier:12667683] RHEA:20697
dbId	3777112
displayName	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
edited	[InstanceEdit:3777111] May, B, 2013-06-26
eventOf	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
input	2 × [SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space] 2 × [SimpleEntity:R-ALL-3341308] O2- [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3777064] Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation [LiteratureReference:3777066] Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS [LiteratureReference:3343716] Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
orthologousEvent	[Reaction:R-SCE-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Saccharomyces cerevisiae [Reaction:R-SPO-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Schizosaccharomyces pombe [Reaction:R-DDI-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Dictyostelium discoideum [Reaction:R-CEL-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Caenorhabditis elegans [Reaction:R-DME-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Drosophila melanogaster [Reaction:R-GGA-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Gallus gallus [Reaction:R-XTR-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Xenopus tropicalis [Reaction:R-DRE-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Danio rerio [Reaction:R-SSC-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Sus scrofa [Reaction:R-BTA-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Bos taurus [Reaction:R-CFA-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Canis familiaris [Reaction:R-RNO-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Rattus norvegicus [Reaction:R-MMU-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Mus musculus
output	[SimpleEntity:R-ALL-189481] H2O2 [mitochondrial intermembrane space] [SimpleEntity:R-ALL-189461] O2 [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-HSA-3780979] CCS transfers Cu to SOD1 (mitochondrial) - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3777112
summation	[Summation:3780967] A portion of SOD1 is located in the mitochondrial intermembr...

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[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species

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