Reactome | CCS transfers Cu to SOD1 (mitochondrial)

Schema > Reaction > Entries

authored	[InstanceEdit:3779419] May, B, 2013-06-27
category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:3780988] May, B, 2013-06-27
dbId	3780979
displayName	CCS transfers Cu to SOD1 (mitochondrial)
edited	[InstanceEdit:3779419] May, B, 2013-06-27
eventOf	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species - Homo sapiens
followingEvent	[Reaction:R-HSA-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) - Homo sapiens
inferredFrom	[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 - Homo sapiens [Reaction:R-MMU-3780963] Ccs transfers Cu to Sod1 - Mus musculus
input	2 × [Complex:R-HSA-3780962] CCS:SOD1 dimer [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CCS transfers Cu to SOD1 (mitochondrial)
output	[Complex:R-HSA-3780978] CCS dimer [mitochondrial intermembrane space] [Complex:R-HSA-3777109] SOD1 dimer [mitochondrial intermembrane space]
precedingEvent	[Reaction:R-HSA-3780958] SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4837339] Kavdia, Mahendra, 2013-11-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3780979
summation	[Summation:3780970] As inferred from the cytosolic reaction and from the mitocho...

(precedingEvent)	[Reaction:R-HSA-3777112] SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
(hasEvent)	[Pathway:R-HSA-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-3299753] CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 [Reaction:R-MMU-3780963] Ccs transfers Cu to Sod1

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