SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)

Stable Identifier
R-HSA-3777112
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space
ReviewStatus
5/5
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SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)
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A portion of SOD1 is located in the mitochondrial intermembrane space (IMS) where it catalyzes the formation of oxygen (O2) and hydrogen peroxide (H2O2) from superoxide (O2.-) (He et al. 2011, Higgins et al. 2002, inferred from rat in Okado-Matsumoto and Fridovich 2001).

Literature References
PubMed ID Title Journal Year
11507097 Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

Fridovich, I, Okado-Matsumoto, A

J. Biol. Chem. 2001
11886899 Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

Xu, Z, Ding, H, Higgins, CM, Jung, C

J. Neurosci. 2002
21393238 Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation

Spitz, DR, Ryan, AJ, McCormick, ML, Murthy, S, He, C, Carter, AB

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

superoxide dismutase activity of SOD1 dimer [mitochondrial intermembrane space]

Physical Entity
SOD1 dimer [mitochondrial intermembrane space] (Homo sapiens)
Activity
superoxide dismutase activity (GO:0004784)
Orthologous Events
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Bos taurus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Caenorhabditis elegans)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Canis familiaris)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Danio rerio)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Dictyostelium discoideum)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Drosophila melanogaster)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Gallus gallus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Mus musculus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Rattus norvegicus)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Saccharomyces cerevisiae)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Schizosaccharomyces pombe)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Sus scrofa)
SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) (Xenopus tropicalis)
Cross References
Rhea
Authored
May, B  (2013-06-26)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-26)
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