SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)

Stable Identifier
R-HSA-3777112
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A portion of SOD1 is located in the mitochondrial intermembrane space (IMS) where it catalyzes the formation of oxygen (O2) and hydrogen peroxide (H2O2) from superoxide (O2.-) (He et al. 2011, Higgins et al. 2002, inferred from rat in Okado-Matsumoto and Fridovich 2001).

Literature References
PubMed ID Title Journal Year
11507097 Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

Fridovich, I, Okado-Matsumoto, A

J. Biol. Chem. 2001
11886899 Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

Xu, Z, Ding, H, Higgins, CM, Jung, C

J. Neurosci. 2002
21393238 Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation

Spitz, DR, Ryan, AJ, McCormick, ML, Murthy, S, He, C, Carter, AB

J. Biol. Chem. 2011
Participants
Participates
Catalyst Activity

superoxide dismutase activity of SOD1 dimer [mitochondrial intermembrane space]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!