DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

Stable Identifier
R-HSA-3772436
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Stimulation of the WNT pathway controls the activity of PIP5KB in a FZD- and DVL-dependent manner (Pan et al, 2008; Bilic et al, 2007; Cong et al, 2004; Qin et al, 2009). Activation of PIP5KB results in the formation of PI(4,5)P2 at the plasma membrane, which is required through an unclear mechanism for the phosphorylation of LRP6 at serine 1490, LRP6 aggregation into 'signalosomes' and LRP6 phosphorylation at threonine 1479. These events are required for the recruitment of AXIN to the plasma membrane (Pan et al, 2008; Qin et al, 2009).

Literature References
PubMed ID Title Journal Year
17569865 Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

Bilic, J, Huang, YL, Davidson, G, Zimmermann, T, Cruciat, CM, Bienz, M, Niehrs, C

Science 2007
19561074 Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl

Qin, Y, Li, L, Pan, W, Wu, D

J. Biol. Chem. 2009
15459103 Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Cong, F, Schweizer, L, Varmus, H

Development 2004
18772438 Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation

Pan, W, Choi, SC, Wang, H, Qin, Y, Volpicelli-Daley, L, Swan, L, Lucast, L, Khoo, C, Zhang, X, Li, L, Abrams, CS, Sokol, SY, Wu, D

Science 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-4-phosphate 5-kinase activity of ppDVL:PIP5K1B [cytosol]
Physical Entity
Activity
Orthologous Events
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Created