DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

Stable Identifier
Reaction [transition]
Homo sapiens
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Stimulation of the WNT pathway controls the activity of PIP5KB in a FZD- and DVL-dependent manner (Pan et al, 2008; Bilic et al, 2007; Cong et al, 2004; Qin et al, 2009). Activation of PIP5KB results in the formation of PI(4,5)P2 at the plasma membrane, which is required through an unclear mechanism for the phosphorylation of LRP6 at serine 1490, LRP6 aggregation into 'signalosomes' and LRP6 phosphorylation at threonine 1479. These events are required for the recruitment of AXIN to the plasma membrane (Pan et al, 2008; Qin et al, 2009).
Literature References
PubMed ID Title Journal Year
19561074 Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl

Pan, W, Li, L, Qin, Y, Wu, D

J. Biol. Chem. 2009
17569865 Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

Niehrs, C, Cruciat, CM, Bienz, M, Zimmermann, T, Huang, YL, Bilic, J, Davidson, G

Science 2007
15459103 Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP

Schweizer, L, Cong, F, Varmus, H

Development 2004
18772438 Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation

Lucast, L, Zhang, X, Choi, SC, Swan, L, Abrams, CS, Sokol, SY, Wu, D, Pan, W, Li, L, Volpicelli-Daley, L, Wang, H, Qin, Y, Khoo, C

Science 2008
Catalyst Activity

1-phosphatidylinositol-4-phosphate 5-kinase activity of ppDVL:PIP5K1B [cytosol]

Orthologous Events
Cross References
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