Stimulation of the WNT pathway controls the activity of PIP5KB in a FZD- and DVL-dependent manner (Pan et al, 2008; Bilic et al, 2007; Cong et al, 2004; Qin et al, 2009). Activation of PIP5KB results in the formation of PI(4,5)P2 at the plasma membrane, which is required through an unclear mechanism for the phosphorylation of LRP6 at serine 1490, LRP6 aggregation into 'signalosomes' and LRP6 phosphorylation at threonine 1479. These events are required for the recruitment of AXIN to the plasma membrane (Pan et al, 2008; Qin et al, 2009).
Pan, W, Li, L, Qin, Y, Wu, D
Niehrs, C, Cruciat, CM, Bienz, M, Zimmermann, T, Huang, YL, Bilic, J, Davidson, G
Schweizer, L, Cong, F, Varmus, H
Lucast, L, Zhang, X, Choi, SC, Swan, L, Abrams, CS, Sokol, SY, Wu, D, Pan, W, Li, L, Volpicelli-Daley, L, Wang, H, Qin, Y, Khoo, C
1-phosphatidylinositol-4-phosphate 5-kinase activity of ppDVL:PIP5K1B [cytosol]
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