Reactome | DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

Stable Identifier

R-HSA-3772436

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

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Stimulation of the WNT pathway controls the activity of PIP5KB in a FZD- and DVL-dependent manner (Pan et al, 2008; Bilic et al, 2007; Cong et al, 2004; Qin et al, 2009). Activation of PIP5KB results in the formation of PI(4,5)P2 at the plasma membrane, which is required through an unclear mechanism for the phosphorylation of LRP6 at serine 1490, LRP6 aggregation into 'signalosomes' and LRP6 phosphorylation at threonine 1479. These events are required for the recruitment of AXIN to the plasma membrane (Pan et al, 2008; Qin et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
17569865	Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation Bilic, J, Huang, YL, Davidson, G, Zimmermann, T, Cruciat, CM, Bienz, M, Niehrs, C	Science	2007
19561074	Regulation of phosphatidylinositol kinases and metabolism by Wnt3a and Dvl Qin, Y, Li, L, Pan, W, Wu, D	J. Biol. Chem.	2009
15459103	Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP Cong, F, Schweizer, L, Varmus, H	Development	2004
18772438	Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation Pan, W, Choi, SC, Wang, H, Qin, Y, Volpicelli-Daley, L, Swan, L, Lucast, L, Khoo, C, Zhang, X, Li, L, Abrams, CS, Sokol, SY, Wu, D	Science	2008