Reactome | WNT signaling stimulates CSNK1-dependent phosphorylation of DVL

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WNT signaling stimulates CSNK1-dependent phosphorylation of DVL Show undefined attributes

authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:3965463] protein serine/threonine kinase activity of CSNK1E [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3772437] Rothfels, K, 2013-06-24
dbId	3772435
displayName	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf	[Pathway:R-HSA-201688] WNT mediated activation of DVL - Homo sapiens
followingEvent	[Reaction:R-HSA-3772434] Phosphorylated DVL recruits PIP5K1B to the plasma membrane - Homo sapiens [Reaction:R-HSA-1504188] FZD recruits DVL to the receptor complex - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-201689] p-DVL [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3772361] Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases [LiteratureReference:3772364] Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling [LiteratureReference:3772332] Casein kinase I transduces Wnt signals [LiteratureReference:208035] Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex [LiteratureReference:3772330] Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin [LiteratureReference:3772366] Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon [LiteratureReference:208081] Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WNT signaling stimulates CSNK1-dependent phosphorylation of DVL
orthologousEvent	[Reaction:R-CEL-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Caenorhabditis elegans [Reaction:R-DME-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Drosophila melanogaster [Reaction:R-GGA-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Gallus gallus [Reaction:R-XTR-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Xenopus tropicalis [Reaction:R-DRE-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Danio rerio [Reaction:R-SSC-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Sus scrofa [Reaction:R-BTA-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Bos taurus [Reaction:R-RNO-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Rattus norvegicus [Reaction:R-MMU-3772435] WNT signaling stimulates CSNK1-dependent phosphorylation of DVL - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-3772407] pp-DVL [cytosol]
precedingEvent	[Reaction:R-HSA-201717] CSNK2-mediated phosphorylation of DVL - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3772435
summation	[Summation:3772438] CSNK1E and DVL physically interact in vivo and CSNK1E phosph...

Referrals

(precedingEvent)	[Reaction:R-HSA-3772434] Phosphorylated DVL recruits PIP5K1B to the plasma membrane [Reaction:R-HSA-1504188] FZD recruits DVL to the receptor complex
(hasEvent)	[Pathway:R-HSA-201688] WNT mediated activation of DVL

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