WNT signaling stimulates CSNK1-dependent phosphorylation of DVL

Stable Identifier
Reaction [transition]
Homo sapiens
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CSNK1E and DVL physically interact in vivo and CSNK1E phosphorylates DVL in response to WNT signaling (Peters et al, 1999; Sakanaka et al, 1999; Kishida et al, 2001; Gao et al, 2002; Hino et al, 2003; Klimowski et al, 2006; Bernatik et al, 2011). Phosphorylation by CSNK1E in the PDZ domain of DVL appears to be required for the recruitment of AXIN and the subsequent phosphorylation of LRP6 (Bernatik et al, 2011).
Literature References
PubMed ID Title Journal Year
11425858 Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon

Kishida, M, Kikuchi, A, Asashima, M, Hino, S, Kishida, S, Michiue, T, Fukui, A, Yamamoto, H

J. Biol. Chem. 2001
10517632 Casein kinase I transduces Wnt signals

Peters, JM, McKay, JP, McKay, RM, Graff, JM

Nature 1999
16965538 Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling

Garcia, BA, Shabanowitz, J, Virshup, DM, Klimowski, LK, Hunt, DF

FEBS J. 2006
12556519 Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin

Kikuchi, A, Asashima, M, Hino, S, Michiue, T

J. Biol. Chem. 2003
10535959 Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function

Leong, P, Xu, L, Harrison, SD, Sakanaka, C, Williams, LT

Proc Natl Acad Sci U S A 1999
11818547 Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex

Virshup, DM, Yochum, A, Seeling, JM, Hill, V, Gao, ZH

Proc Natl Acad Sci U S A 2002
21285348 Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases

Polonio, T, Schulte, G, Bernatik, O, Bryja, V, Konik, P, Ganji, RS, Krejci, P, Cervenka, I, Dijksterhuis, JP

J. Biol. Chem. 2011
Catalyst Activity

protein serine/threonine kinase activity of CSNK1E [cytosol]

Orthologous Events
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