CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).
Xu, W, Clements, WK, Graham, TA, Kimelman, D
Morishita, Y, Shibuya, H, Hyodo, J, Tago, K, Akiyama, T, Ohwada, S, Adachi, S, Nakamura, T, Nagai, S, Murata, Y, Nishita, M
Daniels, DL, Weis, WI
© 2022 Reactome
