CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).
Tago, K, Nakamura, T, Nishita, M, Hyodo, J, Nagai, S, Murata, Y, Adachi, S, Ohwada, S, Morishita, Y, Shibuya, H, Akiyama, T
Graham, TA, Clements, WK, Kimelman, D, Xu, W
Daniels, DL, Weis, WI
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