Reactome | CTNNBIP1 binds beta-catenin

CTNNBIP1 binds beta-catenin

Stable Identifier

R-HSA-3772430

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10898789	Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein Tago, K, Nakamura, T, Nishita, M, Hyodo, J, Nagai, S, Murata, Y, Adachi, S, Ohwada, S, Morishita, Y, Shibuya, H, Akiyama, T	Genes Dev.	2000
12408824	The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT Graham, TA, Clements, WK, Kimelman, D, Xu, W	Mol. Cell	2002
12408825	ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules Daniels, DL, Weis, WI	Mol. Cell	2002