CTNNBIP1 binds beta-catenin

Stable Identifier
Reaction [binding]
Homo sapiens
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CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).

Literature References
PubMed ID Title Journal Year
12408824 The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT

Xu, W, Clements, WK, Graham, TA, Kimelman, D

Mol. Cell 2002
10898789 Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein

Morishita, Y, Shibuya, H, Hyodo, J, Tago, K, Akiyama, T, Ohwada, S, Adachi, S, Nakamura, T, Nagai, S, Murata, Y, Nishita, M

Genes Dev. 2000
12408825 ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

Daniels, DL, Weis, WI

Mol. Cell 2002
Orthologous Events
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