CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein th...

created [InstanceEdit:3772429] Rothfels, K, 2013-06-24
dbId 3772428
displayName CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein th...
modified [InstanceEdit:4652706] Rothfels, K, 2013-10-02
schemaClass Summation
text CTNNBIP1 (also known as ICAT) is an 81 amino-acid protein that was identified in a two-hybrid screen to identify beta-catenin interacting partners (Tago et al, 2000). CTNNBIP1 binds directly to beta-catenin in vitro and in vivo and interferes with the formation of a TCF/LEF:beta-catenin complex (Tago et al, 2000; Daniels and Weiss et al, 2002; Graham et al, 2002). Expression of CTNNBIP1 abrogates expression of a WNT-dependent reporter gene (Tago et al, 2000).
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