Reactome | Netrin-1 signaling

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Netrin-1 signaling Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911822
displayName	Netrin-1 signaling
eventOf	[Pathway:R-DME-422475] Axon guidance - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-374662] Translocation of Ezrin to plasma membrane - Drosophila melanogaster [Reaction:R-DME-374664] Phosphorylation and activation of Ezrin - Drosophila melanogaster [Reaction:R-DME-374663] DCC interaction with Ezrin - Drosophila melanogaster [Reaction:R-DME-593685] Netrin-4 binds DCC/UNC5A - Drosophila melanogaster [Pathway:R-DME-376172] DSCAM interactions - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-373752] Netrin-1 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Netrin-1 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-373752
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-422475] Axon guidance
(inferredTo)	[Pathway:R-HSA-373752] Netrin-1 signaling

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