Reactome | DCC interaction with SIAH2

Schema > Reaction > Entries

authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:374668] Garapati, P V, 2008-07-30 10:22:51
dbId	374667
displayName	DCC interaction with SIAH2
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
eventOf	[Pathway:R-HSA-373752] Netrin-1 signaling - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5433471] negative regulation of netrin-activated signaling pathway
input	[Complex:R-HSA-373667] DCC:NTN1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-374566] SIAH2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:374480] Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DCC interaction with SIAH2
output	[Complex:R-HSA-374590] NTN1:DCC:SIAH2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-373711] DCC interaction with Netrin-1 - Homo sapiens
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-374667
summation	[Summation:374639] Siah-2 binds to the DCC protein and promote its proteolysis ...

(hasEvent)

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