Reactome | CX3CR1 binds CX3CL1

CX3CR1 binds CX3CL1

Stable Identifier

R-HSA-373342

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        CX3CR1 binds CX3CL1 (Homo sapiens)

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CX3CL1 (fractalkine) is a member of the chemokine superfamily and functions as a human leukocyte chemoattractant protein (Bazan JF et al, 1997). Unlike other human chemokines, the chemokine domain of fractalkine has three amino acids between two conserved cysteines, referred to as the CX3C motif. This molecule can exist in two forms: either membrane-anchored or as a shed 95K glycoprotein. The soluble form has potent chemoattractant activity for T-cells and monocytes, and the membrane-bound protein, which is induced on activated primary endothelial cells, promotes strong adhesion of those leukocytes. The seven-transmembrane high-affinity receptor for fractalkine, termed CX3C1, mediates both the adhesive and migratory functions of fractalkine (Imai T et al, 1997). CX3CL1 is reported to signal via Gi (Brandt et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9390561	Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion Yoshie, O, Nishimura, M, Takagi, S, Haskell, C, Schall, TJ, Baba, M, Hieshima, K, Kakizaki, M, Nagira, M, Nomiyama, H, Imai, T	Cell	1997
9024663	A new class of membrane-bound chemokine with a CX3C motif Greaves, DR, Soo, K, Zlotnik, A, Rossi, D, Schall, TJ, Hardiman, G, Bacon, KB, Bazan, JF, Wang, W	Nature	1997