In the presence of the proteasome inhibitor MG132, polyubiqu...

created [InstanceEdit:3640832] Rothfels, K, 2013-05-29
dbId 3640831
displayName In the presence of the proteasome inhibitor MG132, polyubiqu...
schemaClass Summation
text In the presence of the proteasome inhibitor MG132, polyubiquitinated forms of AXIN accumulate (Huang et al, 2009; Zhang et al, 2011; Callow et al, 2011). This effect is abrogated by co-treatment of cells with both MG132 and inhibitors of tankyrase activity, suggesting that both PARSylation and ubiquitination are required for AXIN degradation (Huang et al, 2009).
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