SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

Stable Identifier
R-HSA-352029
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
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The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).
Literature References
PubMed ID Title Journal Year
7589472 Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney

Romeo, G, Barone, V, Galietta, LJ, Rasola, A, Bagnasco, S

FEBS Lett 1995
10358010 Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes

Risler, T, Matskevitch, I, Handler, JS, Waldegger, S, Stegen, C, Noll, B, Busch, AE, Lang, F, Wagner, CA, Kwon, HM, Broer, S

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

amino acid transmembrane transporter activity of SLC6A12 [plasma membrane]

Physical Entity
SLC6A12 [plasma membrane] (Homo sapiens)
Activity
amino acid transmembrane transporter activity (GO:0015171)
Orthologous Events
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Bos taurus)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Canis familiaris)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Danio rerio)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Gallus gallus)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Mus musculus)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Plasmodium falciparum)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Rattus norvegicus)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Sus scrofa)
SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Xenopus tropicalis)
Authored
D'Eustachio, P  (2008-06-03)
Reviewed
Jassal, B  (2008-06-03)
Created
D'Eustachio, P  (2008-05-30)
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