Reactome | SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

Stable Identifier

R-HSA-352029

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Locations in the PathwayBrowser

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Transport of small molecules (Homo sapiens)

- SLC-mediated transmembrane transport (Homo sapiens)
  - Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
    - Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
      - SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)
  - Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
    - Amino acid transport across the plasma membrane (Homo sapiens)
      - SLC6A12 (BGT-1)-mediated uptake of GABA and betaine (Homo sapiens)

General

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SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

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The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10358010	Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes Matskevitch, I, Wagner, CA, Stegen, C, Broer, S, Noll, B, Risler, T, Kwon, HM, Handler, JS, Waldegger, S, Busch, AE, Lang, F	J Biol Chem	1999
7589472	Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney Rasola, A, Galietta, LJ, Barone, V, Romeo, G, Bagnasco, S	FEBS Lett	1995