The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).
Romeo, G, Barone, V, Galietta, LJ, Rasola, A, Bagnasco, S
Risler, T, Matskevitch, I, Handler, JS, Waldegger, S, Stegen, C, Noll, B, Busch, AE, Lang, F, Wagner, CA, Kwon, HM, Broer, S
amino acid transmembrane transporter activity of SLC6A12 [plasma membrane]
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