The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).
Matskevitch, I, Wagner, CA, Stegen, C, Broer, S, Noll, B, Risler, T, Kwon, HM, Handler, JS, Waldegger, S, Busch, AE, Lang, F
Rasola, A, Galietta, LJ, Barone, V, Romeo, G, Bagnasco, S
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