Reactome | SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

Stable Identifier

R-HSA-352029

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
7589472	Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney Rasola, A, Galietta, LJ, Barone, V, Romeo, G, Bagnasco, S	FEBS Lett	1995
10358010	Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes Matskevitch, I, Wagner, CA, Stegen, C, Broer, S, Noll, B, Risler, T, Kwon, HM, Handler, JS, Waldegger, S, Busch, AE, Lang, F	J Biol Chem	1999