Reactome | Phosphorylation of COP1 at Ser-387 by ATM

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Phosphorylation of COP1 at Ser-387 by ATM Show undefined attributes

authored	[InstanceEdit:353601] Matthews, L, 2008-06-12 21:09:06
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:349466] Matthews, L, 2008-05-07 22:49:21
dbId	349444
displayName	Phosphorylation of COP1 at Ser-387 by ATM
edited	[InstanceEdit:446052] Matthews, L, 2009-10-21
eventOf	[Pathway:R-HSA-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Homo sapiens
followingEvent	[Reaction:R-HSA-264418] Translocation of COP1 from the nucleus to the cytoplasm - Homo sapiens [Reaction:R-HSA-264435] Dissociation of the COP1-p53 complex - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-349454] RFWD2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:349437] ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Phosphorylation of COP1 at Ser-387 by ATM
orthologousEvent	[Reaction:R-DDI-349444] Phosphorylation of COP1 at Ser-387 by ATM - Dictyostelium discoideum [Reaction:R-GGA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Gallus gallus [Reaction:R-DRE-349444] Phosphorylation of COP1 at Ser-387 by ATM - Danio rerio [Reaction:R-SSC-349444] Phosphorylation of COP1 at Ser-387 by ATM - Sus scrofa [Reaction:R-BTA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Bos taurus [Reaction:R-CFA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Canis familiaris [Reaction:R-RNO-349444] Phosphorylation of COP1 at Ser-387 by ATM - Rattus norvegicus [Reaction:R-MMU-349444] Phosphorylation of COP1 at Ser-387 by ATM - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-349450] p-S387-RFWD2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446711] Dixit, VM, 2009-11-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-349444
summation	[Summation:349436] ATM phosphorylates COP1 on Ser387 in response to DNA damage ...
updateTrackers	[UpdateTracker:9784060] Update Tracker - [Reaction:349444] Phosphorylation of COP1 at Ser-387 by ATM - v54:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9784060] Update Tracker - [Reaction:349444] Phosphorylation of COP1 at Ser-387 by ATM - v54:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-349425] Autodegradation of the E3 ubiquitin ligase COP1
(precedingEvent)	[Reaction:R-HSA-264418] Translocation of COP1 from the nucleus to the cytoplasm [Reaction:R-HSA-264435] Dissociation of the COP1-p53 complex