Reactome | Phosphorylation of COP1 at Ser-387 by ATM

Schema > Reaction > Entries

Phosphorylation of COP1 at Ser-387 by ATM Show undefined attributes

catalystActivity	[CatalystActivity:10578457] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10578459
displayName	Phosphorylation of COP1 at Ser-387 by ATM
eventOf	[Pathway:R-DRE-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-264418] Translocation of COP1 from the nucleus to the cytoplasm - Danio rerio [Reaction:R-DRE-264435] Dissociation of the COP1-p53 complex - Danio rerio
inferredFrom	[Reaction:R-HSA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DRE-349454] cop1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of COP1 at Ser-387 by ATM
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DRE-349450] phospho-cop1 [nucleoplasm]
precedingEvent	[Reaction:R-DRE-5693540] MRN activates ATM - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-349444
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-349425] Autodegradation of the E3 ubiquitin ligase COP1
(precedingEvent)	[Reaction:R-DRE-264418] Translocation of COP1 from the nucleus to the cytoplasm [Reaction:R-DRE-264435] Dissociation of the COP1-p53 complex
(inferredTo)	[Reaction:R-HSA-349444] Phosphorylation of COP1 at Ser-387 by ATM

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