Reactome | Autoubiquitination of phospho-COP1(Ser-387 )

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Autoubiquitination of phospho-COP1(Ser-387 ) Show undefined attributes

authored	[InstanceEdit:353601] Matthews, L, 2008-06-12 21:09:06
catalystActivity	[CatalystActivity:349467] ubiquitin-protein transferase activity of p-S387-RFWD2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:264445] Matthews, L, 2008-03-31 11:53:02
dbId	264444
displayName	Autoubiquitination of phospho-COP1(Ser-387 )
edited	[InstanceEdit:349470] Matthews, L, 2008-04-30 12:41:30
eventOf	[Pathway:R-HSA-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-264458] Proteasome mediated degradation of COP1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-349439] p-S387-RFWD2 [cytosol] 4 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:349437] ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Autoubiquitination of phospho-COP1(Ser-387 )
negativePrecedingEvent	[NegativePrecedingEvent:9749040] Abundant Molecules: Proteasome mediated degradation of COP1 [NegativePrecedingEvent:9749038] Abundant Molecules: Proteolytic degradation of ubiquitinated-Cdc25A [NegativePrecedingEvent:9766475] Futile Cycle: GTSE1 facilitates proteasome-mediated degradation of TP53
orthologousEvent	[Reaction:R-DDI-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Dictyostelium discoideum [Reaction:R-GGA-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Gallus gallus [Reaction:R-XTR-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Xenopus tropicalis [Reaction:R-DRE-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Danio rerio [Reaction:R-SSC-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Sus scrofa [Reaction:R-BTA-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Bos taurus [Reaction:R-CFA-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Canis familiaris [Reaction:R-RNO-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Rattus norvegicus [Reaction:R-MMU-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Mus musculus
output	[Complex:R-HSA-349433] ubiquitinated phospho-COP1(ser-387) [cytosol]
precedingEvent	[Reaction:R-HSA-264418] Translocation of COP1 from the nucleus to the cytoplasm - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446711] Dixit, VM, 2009-11-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-264444
summation	[Summation:349434] ATM phosphorylation promotes autoubiquitination of COP1 in v...
updateTrackers	[UpdateTracker:9791035] Update Tracker - [Reaction:264444] Autoubiquitination of phospho-COP1(Ser-387 ) - v32:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9791035] Update Tracker - [Reaction:264444] Autoubiquitination of phospho-COP1(Ser-387 ) - v32:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-349425] Autodegradation of the E3 ubiquitin ligase COP1
(precedingEvent)	[BlackBoxEvent:R-HSA-264458] Proteasome mediated degradation of COP1