Reactome | Caspase-8 and FLIP(L) processing at DISC

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Caspase-8 and FLIP(L) processing at DISC Show undefined attributes

authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
catalystActivity	[CatalystActivity:139951] cysteine-type endopeptidase activity of active caspase-8 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3465480] Shamovsky, V, 2013-05-17
dbId	3465448
displayName	Caspase-8 and FLIP(L) processing at DISC
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-3371378] Regulation by c-FLIP - Homo sapiens
input	[Complex:R-HSA-3371381] DISC:procaspase-8:FLIP(L) [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1267786] FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity [LiteratureReference:3465386] Mechanism of procaspase-8 activation by c-FLIPL [LiteratureReference:3465412] N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway [LiteratureReference:1267836] Structural and biochemical studies on procaspase-8: new insights on initiator caspase activation [LiteratureReference:3465456] Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL [LiteratureReference:3465334] The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	Caspase-8 and FLIP(L) processing at DISC
orthologousEvent	[BlackBoxEvent:R-DME-3465448] Caspase-8 and FLIP(L) processing at DISC - Drosophila melanogaster [BlackBoxEvent:R-GGA-3465448] Caspase-8 and FLIP(L) processing at DISC - Gallus gallus [BlackBoxEvent:R-DRE-3465448] Caspase-8 and FLIP(L) processing at DISC - Danio rerio [BlackBoxEvent:R-SSC-3465448] Caspase-8 and FLIP(L) processing at DISC - Sus scrofa [BlackBoxEvent:R-BTA-3465448] Caspase-8 and FLIP(L) processing at DISC - Bos taurus [BlackBoxEvent:R-CFA-3465448] Caspase-8 and FLIP(L) processing at DISC - Canis familiaris [BlackBoxEvent:R-RNO-3465448] Caspase-8 and FLIP(L) processing at DISC - Rattus norvegicus [BlackBoxEvent:R-MMU-3465448] Caspase-8 and FLIP(L) processing at DISC - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-3465483] CFLAR(377-480) [cytosol] [Complex:R-HSA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
precedingEvent	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Homo sapiens [Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Homo sapiens [Reaction:R-HSA-3371359] FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3465448
summation	[Summation:3465328] In the presence of FLIP(L), both caspase-8 and FLIP(L) are r...

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[Pathway:R-HSA-3371378] Regulation by c-FLIP

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