Reactome | Regulation by c-FLIP

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Regulation by c-FLIP Show undefined attributes

authored	[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
created	[InstanceEdit:3371404] Shamovsky, V, 2013-05-13
crossReference	[DatabaseIdentifier:12819567] BioModels Database:BIOMD0000000525 [DatabaseIdentifier:12819569] BioModels Database:BIOMD0000000523 [DatabaseIdentifier:12819571] BioModels Database:BIOMD0000000524 [DatabaseIdentifier:12819573] BioModels Database:BIOMD0000000243 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220 [DatabaseIdentifier:12819459] BioModels Database:BIOMD0000000407 [DatabaseIdentifier:12819575] BioModels Database:BIOMD0000000526
dbId	3371378
displayName	Regulation by c-FLIP
edited	[InstanceEdit:3508822] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-140534] Caspase activation via Death Receptors in the presence of ligand - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:3446165] regulation of extrinsic apoptotic signaling pathway via death domain receptors
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Homo sapiens [Reaction:R-HSA-3371359] FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling - Homo sapiens [Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Homo sapiens [BlackBoxEvent:R-HSA-3465448] Caspase-8 and FLIP(L) processing at DISC - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-12-07
literatureReference	[LiteratureReference:1250231] Inhibition of death receptor signals by cellular FLIP [LiteratureReference:1267786] FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity [LiteratureReference:3465386] Mechanism of procaspase-8 activation by c-FLIPL
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Regulation by c-FLIP
orthologousEvent	[Pathway:R-DME-3371378] Regulation by c-FLIP - Drosophila melanogaster [Pathway:R-GGA-3371378] Regulation by c-FLIP - Gallus gallus [Pathway:R-DRE-3371378] Regulation by c-FLIP - Danio rerio [Pathway:R-SSC-3371378] Regulation by c-FLIP - Sus scrofa [Pathway:R-BTA-3371378] Regulation by c-FLIP - Bos taurus [Pathway:R-CFA-3371378] Regulation by c-FLIP - Canis familiaris [Pathway:R-RNO-3371378] Regulation by c-FLIP - Rattus norvegicus [Pathway:R-MMU-3371378] Regulation by c-FLIP - Mus musculus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3371378
summation	[Summation:3465346] c-FLIP proteins (CASP8 and FADD-like apoptosis regulators or...
updateTrackers	[UpdateTracker:9846885] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v83:[updateContainedRLE] [UpdateTracker:9785909] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v51:[removeHasEvent, updateContainedRLE] [UpdateTracker:9776678] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v74:[updateContainedRLE] [UpdateTracker:9847063] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v82:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9846885] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v83:[updateContainedRLE]
[UpdateTracker:9785909] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v51:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9776678] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v74:[updateContainedRLE]
[UpdateTracker:9847063] Update Tracker - [Pathway:3371378] Regulation by c-FLIP - v82:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-140534] Caspase activation via Death Receptors in the presence of ligand

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