Reactome | Caspase-8 and FLIP(L) processing at DISC

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Caspase-8 and FLIP(L) processing at DISC Show undefined attributes

catalystActivity	[CatalystActivity:10235136] cysteine-type endopeptidase activity of active caspase-8 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10283319
displayName	Caspase-8 and FLIP(L) processing at DISC
eventOf	[Pathway:R-CFA-3371378] Regulation by c-FLIP - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-3465448] Caspase-8 and FLIP(L) processing at DISC - Homo sapiens
input	[Complex:R-CFA-3371381] DISC:procaspase-8:FLIP(L) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Caspase-8 and FLIP(L) processing at DISC
output	[EntityWithAccessionedSequence:R-CFA-3465483] CASP8 [cytosol] [Complex:R-CFA-3465431] DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane]
precedingEvent	[Reaction:R-CFA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Canis familiaris [Reaction:R-CFA-3371360] FLIP(L) and procaspase-8 form heterodimer in TNF signaling - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-3465448
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-3371378] Regulation by c-FLIP
(inferredTo)	[BlackBoxEvent:R-HSA-3465448] Caspase-8 and FLIP(L) processing at DISC

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