Reactome | HSF1 activation

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HSF1 activation Show undefined attributes

authored	[InstanceEdit:4793943] Shamovsky, V, 2013-10-28
created	[InstanceEdit:3371552] Shamovsky, V, 2013-05-13
dbId	3371511
displayName	HSF1 activation
edited	[InstanceEdit:5324627] Shamovsky, V, 2014-02-17
eventOf	[Pathway:R-HSA-3371556] Cellular response to heat stress - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:376592] cellular response to heat
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3371586] Dissociation of cytosolic HSF1:HSP90 complex - Homo sapiens [Reaction:R-HSA-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates - Homo sapiens [Reaction:R-HSA-3371591] Trimerization of cytosolic HSF1 - Homo sapiens [BlackBoxEvent:R-HSA-3371527] HSF1 trimer translocates to the nucleus - Homo sapiens [Reaction:R-HSA-5082409] Dissociation of HSF1:HSP90 complex in the nucleus - Homo sapiens [Reaction:R-HSA-5082391] Trimerization of HSF1 in the nucleus - Homo sapiens [Reaction:R-HSA-4793819] HSF1 trimer binds HSE on the target gene - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2014-07-15
literatureReference	[LiteratureReference:5083675] Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation [LiteratureReference:4793657] Multiple layers of regulation of human heat shock transcription factor 1
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	HSF1 activation
orthologousEvent	[Pathway:R-SCE-3371511] HSF1 activation - Saccharomyces cerevisiae [Pathway:R-SPO-3371511] HSF1 activation - Schizosaccharomyces pombe [Pathway:R-DDI-3371511] HSF1 activation - Dictyostelium discoideum [Pathway:R-CEL-3371511] HSF1 activation - Caenorhabditis elegans [Pathway:R-DME-3371511] HSF1 activation - Drosophila melanogaster [Pathway:R-GGA-3371511] HSF1 activation - Gallus gallus [Pathway:R-DRE-3371511] HSF1 activation - Danio rerio [Pathway:R-SSC-3371511] HSF1 activation - Sus scrofa [Pathway:R-BTA-3371511] HSF1 activation - Bos taurus [Pathway:R-CFA-3371511] HSF1 activation - Canis familiaris [Pathway:R-RNO-3371511] HSF1 activation - Rattus norvegicus [Pathway:R-MMU-3371511] HSF1 activation - Mus musculus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5324628] Pani, Bibhusita, 2014-02-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3371511
summation	[Summation:4793868] Heat shock factor 1 (HSF1) is a transcription factor that ac...
updateTrackers	[UpdateTracker:9786479] Update Tracker - [Pathway:3371511] HSF1 activation - v49:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9786479] Update Tracker - [Pathway:3371511] HSF1 activation - v49:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-3371556] Cellular response to heat stress

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