Reactome | HSF1 activation

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HSF1 activation Show undefined attributes

created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10445370
displayName	HSF1 activation
eventOf	[Pathway:R-BTA-3371556] Cellular response to heat stress - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:376592] cellular response to heat
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-3371586] Dissociation of cytosolic HSF1:HSP90 complex - Bos taurus [Reaction:R-BTA-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates - Bos taurus [Reaction:R-BTA-3371591] Trimerization of cytosolic HSF1 - Bos taurus [BlackBoxEvent:R-BTA-3371527] HSF1 trimer translocates to the nucleus - Bos taurus [Reaction:R-BTA-5082409] Dissociation of HSF1:HSP90 complex in the nucleus - Bos taurus [Reaction:R-BTA-5082391] Trimerization of HSF1 in the nucleus - Bos taurus
inferredFrom	[Pathway:R-HSA-3371511] HSF1 activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HSF1 activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-3371511
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-3371556] Cellular response to heat stress
(inferredTo)	[Pathway:R-HSA-3371511] HSF1 activation

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