Reactome | STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

Schema > Reaction > Entries

STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11117287
displayName	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
eventOf	[Pathway:R-PFA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-PFA-5618107] ATP binding to HSP90 triggers conformation change - Plasmodium falciparum
inferredFrom	[Reaction:R-HSA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Homo sapiens
input	[EntityWithAccessionedSequence:R-PFA-443857] HOP [cytosol] [Complex:R-PFA-3371441] HSP40:HSP70:ADP:nascent protein [cytosol] [DefinedSet:R-PFA-3371429] HSP90:HSP90 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
output	[CandidateSet:R-PFA-3371594] HSP40s [cytosol] [Complex:R-PFA-3371444] HSP90:STIP1:HSP70:nascent protein [cytosol]
precedingEvent	[Reaction:R-PFA-3371422] ATP hydrolysis by HSP70 - Plasmodium falciparum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-3371503
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-PFA-5618107] ATP binding to HSP90 triggers conformation change
(inferredTo)	[Reaction:R-HSA-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein

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