Reactome | ATP hydrolysis by HSP70

Schema > Reaction > Entries

ATP hydrolysis by HSP70 Show undefined attributes

catalystActivity	[CatalystActivity:10885319] ATP hydrolysis activity of HSP40:HSP70:ATP:nascent protein [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10871105] Wright, Adam, 2024-03-08
dbId	10885321
displayName	ATP hydrolysis by HSP70
eventOf	[Pathway:R-SPO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-SPO-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Schizosaccharomyces pombe
inferredFrom	[Reaction:R-HSA-3371422] ATP hydrolysis by HSP70 - Homo sapiens
input	[Complex:R-SPO-3371563] HSP40:HSP70:ATP:nascent protein [cytosol]
isInDisease	false
isInferred	true
name	ATP hydrolysis by HSP70
output	[Complex:R-SPO-3371441] HSP40:HSP70:ADP:nascent protein [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SPO-3371590] HSP70 binds to HSP40:nascent protein - Schizosaccharomyces pombe
regulatedBy	[PositiveRegulation:10885322] Positive regulation by 'HSP40s [cytosol]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-3371422
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-SPO-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein
(inferredTo)	[Reaction:R-HSA-3371422] ATP hydrolysis by HSP70