Reactome | Viral DNA cleavage by TREX1

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Viral DNA cleavage by TREX1 Show undefined attributes

authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
catalystActivity	[CatalystActivity:3245941] 3'-5' exonuclease activity of TREX1:viral DNA [endoplasmic reticulum membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:3245940] Shamovsky, V, 2013-03-28
dbId	3245943
displayName	Viral DNA cleavage by TREX1
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-3248023] Regulation by TREX1 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-3244619] TREX1:viral DNA [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2453986] The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Viral DNA cleavage by TREX1
output	[SimpleEntity:R-ALL-109386] dAMP [cytosol] [SimpleEntity:R-ALL-109378] dCMP [cytosol] [SimpleEntity:R-ALL-109327] dGMP [cytosol] [SimpleEntity:R-ALL-109366] TMP [cytosol] [Complex:R-HSA-3244607] TREX1 dimer [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-3244605] TREX1 binds retroviral-derived DNA - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-3245943
summation	[Summation:3248005] TREX1 digests unpaired nucleotides on ssDNA and dsDNA ends t...

Referrals

(hasEvent)	[Pathway:R-HSA-3248023] Regulation by TREX1
(precedingEvent)	[NegativePrecedingEvent:9764719] Futile Cycle: Viral DNA cleavage by TREX1

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