Reactome | TREX1 binds retroviral-derived DNA

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TREX1 binds retroviral-derived DNA Show undefined attributes

authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
category	binding
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
dbId	3244605
displayName	TREX1 binds retroviral-derived DNA
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-3248023] Regulation by TREX1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3245943] Viral DNA cleavage by TREX1 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29926] Mg2+ [cytosol] [Complex:R-HSA-3244607] TREX1 dimer [endoplasmic reticulum membrane] 2 × [Complex:R-HIV-177535] viral DNA with 3' sticky ends [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2453986] The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 [LiteratureReference:3247964] Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TREX1 binds retroviral-derived DNA
negativePrecedingEvent	[NegativePrecedingEvent:9764719] Futile Cycle: Viral DNA cleavage by TREX1
output	[Complex:R-HSA-3244619] TREX1:viral DNA [endoplasmic reticulum membrane]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3244605
summation	[Summation:3247969] TREX1 was shown to bind and degrade the HIV DNA fragments, w...

Referrals

(hasEvent)	[Pathway:R-HSA-3248023] Regulation by TREX1
(precedingEvent)	[BlackBoxEvent:R-HSA-3245943] Viral DNA cleavage by TREX1

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