Reactome | TREX1:viral DNA [endoplasmic reticulum membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:3245941] 3'-5' exonuclease activity of TREX1:viral DNA [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane
consumedByEvent	[BlackBoxEvent:R-HSA-3245943] Viral DNA cleavage by TREX1 - Homo sapiens
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
dbId	3244619
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
displayName	TREX1:viral DNA [endoplasmic reticulum membrane]
hasComponent	4 × [SimpleEntity:R-ALL-29926] Mg2+ [cytosol] [Complex:R-HSA-3244607] TREX1 dimer [endoplasmic reticulum membrane] 2 × [Complex:R-HIV-177535] viral DNA with 3' sticky ends [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
literatureReference	[LiteratureReference:2453986] The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1 [LiteratureReference:3247960] Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease
modified	[InstanceEdit:8959586] Weiser, JD
name	TREX1:viral DNA
producedByEvent	[Reaction:R-HSA-3244605] TREX1 binds retroviral-derived DNA - Homo sapiens
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-3244619

(output)	[Reaction:R-HSA-3244605] TREX1 binds retroviral-derived DNA
(input)	[BlackBoxEvent:R-HSA-3245943] Viral DNA cleavage by TREX1
(physicalEntity)	[CatalystActivity:3245941] 3'-5' exonuclease activity of TREX1:viral DNA [endoplasmic reticulum membrane]