PIAS3 SUMOylates MITF with SUMO1

Stable Identifier
R-HSA-3232162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS3 SUMOylates MITF with SUMO1 at lysine-289 and lysine-423 (lysine-182 and lysine-316 of the M2 isoform, Miller et al. 2005). SUMOylation reduces transcriptional activation by MITF at promoters containing multiple binding sites for MITF.

Literature References
PubMed ID Title Journal Year
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB

Miller, AJ, Levy, C, Davis, IJ, Razin, E, Fisher, DE

J. Biol. Chem. 2005
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created