PIAS3 SUMOylates MITF with SUMO1

Stable Identifier
R-HSA-3232162
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS3 SUMOylates MITF with SUMO1
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PIAS3 SUMOylates MITF with SUMO1 at lysine-289 and lysine-423 (lysine-182 and lysine-316 of the M2 isoform, Miller et al. 2005). SUMOylation reduces transcriptional activation by MITF at promoters containing multiple binding sites for MITF.
Literature References
PubMed ID Title Journal Year
15507434 Sumoylation of MITF and its related family members TFE3 and TFEB

Miller, AJ, Levy, C, Davis, IJ, Razin, E, Fisher, DE

J. Biol. Chem. 2005
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity

SUMO transferase activity of PIAS3 [nucleoplasm]

Physical Entity
PIAS3 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS3 SUMOylates MITF with SUMO1 (Bos taurus)
PIAS3 SUMOylates MITF with SUMO1 (Caenorhabditis elegans)
PIAS3 SUMOylates MITF with SUMO1 (Danio rerio)
PIAS3 SUMOylates MITF with SUMO1 (Gallus gallus)
PIAS3 SUMOylates MITF with SUMO1 (Mus musculus)
PIAS3 SUMOylates MITF with SUMO1 (Rattus norvegicus)
PIAS3 SUMOylates MITF with SUMO1 (Saccharomyces cerevisiae)
PIAS3 SUMOylates MITF with SUMO1 (Sus scrofa)
Authored
May, B  (2013-03-23)
Reviewed
Fisher, DE  (2015-10-10)
Created
May, B  (2013-03-27)
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